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Serotonin boosts neuronal powerplants protecting against stress


Mitochondria in neurons are the powerhouses that generate energy to execute cellular functions and regulate neuronal survival under conditions of stress. Collaborative research by Prof. Vidita Vaidya and Prof. Ullas Kolthur-Seetharam groups at TIFR, along with Dr. Ashok Vaidya, at Medical Research Centre, Kasturba Health Society, has demonstrated an unusual function for the neurotransmitter serotonin, in the generation of new mitochondria—a process called mitochondrial biogenesis—in neurons, accompanied by increase in cellular respiration and ATP, the energy currency of the cell.


Serotonin boosts neuronal powerplants protecting against stress