K. V. R. Chary, Ph.D.
Professor

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Our research interests are primarily focused on the investigation of the three-dimensional structures and properties of biological molecules, particularly proteins and nucleic acids, in atomic detail and their correlation with biological activity. The methods we use are largely multidimensional and multinuclear NMR techniques. Besides, we use variety of methods based on optical spectroscopy, including fluorescence and circular dichroism. Recently, we started using isothermal titration calorimetry (ITC) and Matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF; TofSpec 2E) in our experimental studies. Besides we also use the techniques of protein chemistry and molecular biology for biosynthetic expression of proteins and their site-directed mutagenesis.

We had been having close collaboration with the National Institutes of Health, Bethesda, Maryland. Under this collaboration, we have an on going Indo-US Research Program entitled "Conformation and Interaction of Non-standard Forms of Nucleic Acids", with Dr. H.T. Miles as the principal investigator from NIH.

We also have close links with the European Union Large Scale Facility for Nuclear Magnetic Resonance in life sciences (CERM) at Florence, Italy. This is part of the Department of Science and Technology (DST) sponsored Indo-Italian collaborative research program. Under this program, we have an ongoing research project entitled "Structure and dynamics of calcium binding proteins".