Curriculum Vitae K.V.R.Chary

1. Name of the candidate: Prof. K.V.R. Chary

2. Date of birth: 10th February, 1954

3. Place of birth: Bhongir, Andhra Pradesh, India

4. Mailing address:

a. Official address:

Prof. K.V.R. Chary
Department of Chemical Sciences, 

Tata Institute of Fundamental Research,
Homi Bhabha Road, Mumbai-400005
Phone: 022-2278 2489; Mobile: 9987260959; Fax: 022-2280 4610
E.mail: chary@tifr.res.in/chary54@gmail.com

 

b. Residential address:

603, Maghnad
TIFR Housing Colony
Homi Bhabha Road, Mumbai-400005 

Phone: 022-2280 2860

 

5. Area of specialization:

Molecular Biophysics, Structural Biology and Nuclear Magnetic Resonance

6. Educational qualifications:

(From Bachelor's degree onwards)

S.No.

Degree

Subject

Class

Year

University

1

B.Sc.

Mathematics, Physics, Chemistry

I class

1974

Osmania University, Hyderabad

2

M.Sc.

Physics

I Class

1976

Osmania University

Hyderabad

3

Ph.D.

Physics

1983

Osmania University, Hyderabad

 

7. Details of professional training and research experience.

2011-Till date: Senior Professor (I), DCS, TIFR, Mumbai, India. (Structure-function relationship of proteins; Structure, conformational heterogeneity and dynamics of a βγ-crystallin domain from Hahella chejuensis. Aggregation behavior of prion protein; Development of rapid NMR techniques for structure determination/refinement/verification and dynamical studies of proteins; Provide a structural and dynamic basis for understanding the way a protein sequence translates into a folded conformation under the influence of Ca2+-concentration; Plant Metabolism (In-cell NMR)).

 

2008-2011: Full Professor (H), Chairperson, Department of Chemical Sciences (DCS), and Dean, Natural Science Faculty (NSF), TIFR, Mumbai, India. (Structure-function relationship of proteins; Studies on archael βγ-crystallin to show its uncanny similarity with mammalian lens crystallins, an evolutionary convergent change. Development of rapid NMR techniques for structure determination/refinement/verification and dynamical studies of proteins; Provide a structural and dynamic basis for understanding the way a protein sequence translates into a folded conformation under the influence of Ca2+-concentration).

 

2002-2008: Full Professor (H), DCS, TIFR, Mumbai, India. (Structure, dynamics and Ca2+-binding properties of Ca2+-binding proteins; Intra- and inter-domain co-operativity in Ca2+-binding and Ca2+-displacement and information about the statistical phenomenon associated with it. Development of new NMR methodologies, with a focus on enhancement of resolution and sensitivity, and the rapidity of data acquisition time. 

 

2001-2002: Associate Professor (G), DCS, TIFR, Mumbai, India. (Unraveling the conformation of biologically important proteins (not amenable to X-ray crystallography), and studying their dynamics and interaction with other biomolecules to understand the structure-function relationships (Example: Proteins involved in the pathogenesis of various diseases; Development of novel methodologies in protein engineering and isotope labeling/specific labeling; Klenow-duplex and triplex DNA interaction)

 

1997-2001: Associate Professor (F), DCS, TIFR, Mumbai, India. (Structural feasibility of a triplex DNA and parallel stranded double helical DNA under physiological pH and temperature conditions; Study of polymerase mediated DNA slippage at its proximal end that influences the fold-back structures at distal end during mononucleotide repeat expansions; Studies on 3D structures of four hairpin DNA containing uracil in their four-base loop. Extrusion of the uracil in a four-base loop of a hairpin DNA was shown to enhance the base excision efficiency by uracil DNA glycosylase: NMR characterization. Development of an automated program for rapid assignment of 1H,13C, and 15N resonances in proteins.

 

1992-1997: Reader (F), Chemical Physics Group/Department of Chemical Sciences (DCS), TIFR, Mumbai, India. (Structural characterization of DNA triplexes; evidence for the pH driven dis-proportionation reaction in DNA; Study of interactions stabilizing base triples, which include mismatched base triples (C+.G-T and T.A+-C; Structural characterization of A-I, A+-G,  A+-C, T-C and G-T mismatched base pairs).

 

1990-1992: Fellow (E), Chemical Physics Group, TIFR, Mumbai, India. (The sequence dependent structural heterogeneity and polymorphism in the conformation of biologically relevant distorted forms of DNA; Development of novel NMR methodologies involving hetero-nuclear [31P-1H] long-range couplings for better description of the DNA structure.

 

1988-1990: Research Collaborator (Visiting Scientist), Institute of Molecular Biology and Biophysics, Eidg. Technische Hochschule, Zurich, Switzerland. (Structural studies on recombinant E. Coli glutaredoxin; Measurement of small heteronuclear 1H-15N coupling constants in 15N-labelled proteins by 3D HNNHAB – COSY, for stereo-specific resonance assignment of pro-chiral groups in proteins; Development of software for the 3D Fourier transformation of 3D NMR data).

 

1985-1988: Research Associate, Chemical Physics Group, TIFR, Mumbai, India. (Studies on the sequence dependent structural heterogeneity in biologically relevant DNA; Development of Novel NMR methodologies for the characterization of sugar puckers and the orientation of individual nucleotide bases with respect to their sugar moiety in nucleic acids).

 

1983-1985: Scientific Officer (C), Tata Institute of Fundamental Research (TIFR), Mumbai, India. (Structural Studies on Lutenizing Hormone and Releasing Hormone and on the sequence dependent structural heterogeneity in DNA; Development of novel NMR methodologies for deriving various structural restraints from NMR parameters). 

 

1976-1983: Research Scholar, Physics Department, University Science College, Osmania University, Hyderabad, India. (Indigenous Design and Construction of a Wide-Line NMR Spectrometer; Studies on phase transitions in some metal complexes; As a Lecturer (1977-1983) at New Science College, Hyderabad, taught Physics to B.Sc., (Hons) students and Electronics to M.Sc (Applied Electronics) students and Bio-physical Instrumentation to M.Sc (Biological Science) students.

 

8. Details of employment.

2011-Till date: Senior Professor (I), Department of Chemical Sciences, TIFR.

 

2008-2011: Full Professor (H) and Chairperson, Department of Chemical Sciences, and Dean, Natural Science Faculty (NSF), TIFR.

 

2002-2008: Full Professor (H), Department of Chemical Sciences, TIFR.

 

2001-2002: Associate Professor (G), Department of Chemical Sciences, TIFR.

 

1997-2001: Associate Professor (F), Department of Chemical Sciences, TIFR.

 

1992-1997: Reader (F), Department of Chemical Sciences, TIFR.

 

1990-1992: Fellow, Department of Chemical Sciences, TIFR.

 

1988-1990: Research Collaborator, Institute of Molecular Biology and Biophysics, Eidg. Technische Hochschule, Zurich, Switzerland.

 

1985-1988: Research Associate, Department of Chemical Sciences, TIFR.

 

1983-1985: Scientific Officer (C), Tata Institute of Fundamental Research.

 

1977-1983: Lecturer, New Science College, Hyderabad; Research Scholar (Part-time), Physics Department, University Science College, Osmania University, Hyderabad.

 

1976-1977: Research Scholar, Physics Department, University Science College, Osmania University, Hyderabad.

 

9. Professional recognitions, awards, fellowships received.

       i.            i.        Fellowships:

 

                                 ·                      Elected Fellow, Indian National Science Academy, New Delhi 2012

                                 ·                      Elected Fellow, Andhra Pradesh Academi of Sciences, 2011

                                 ·                      Elected Fellow, National Academy of Sciences,  2000

 

ii.       Awards:

 

                                 ·                      Professor J.C.Ghosh Memorial Award of the Indian Chemical Society, 2009-2010.

                                 ·                      The "Dharamsi Morarji Chemical Co. Visiting Fellowship in Chemistry" of the Institute of Chemical Technology, Mumbai, for the year 2010-11.

                                 ·                      Professor Rango Krishna Asundi Memorial Lecture Award of Indian National Science Academy, New Delhi 2006.

                                 ·                      Anil Kumar Bose Memorial Award, Indian National Science Academy, New Delhi 1989

                                 ·                      Young Scientist Medal, Indian National Science Academy, New Delhi 1986

                                 ·                      Young Scientist Award, BRUKER, 1986.

 

iii.      Distinctions:

 

 

iv.      International Conferences Organized

 

                                 ·                      Member and Scientific Secretary, Organizing Committee of International Conference of Magnetic Resonance in Biological Systems held at Hyderabad, India, during January 16-21, 2005

                                 ·                      Member, National Organizing Committee on International Workshop on Recent trends in Solid State NMR in Biological systems, Bangalore, January 24-26, 2005.

                                 ·                      Member, National Organizing Committee on International Workshop on Recent Trends in Biomedical NMR, New Delhi, January 12-14, 2005.

                                 ·                      Member and Treasurer, International Symposium on Magnetic Resonance and Biomolecular Structure and Function, at TIFR, Jan 17-20, 2000

                                 ·                      Member and Treasurer, International Symposium on Recent Trends in Biomedical Research, at TIFR, Mumbai during September 27-29, 1999.

 

v.       Chaired Sessions at International Conferences

 

 

vi.      Reviewer for International Journals:

 

The Journals include Structure (USA), Biochemistry (USA), Journal Biomolecular NMR (The Netherlands), Current Bioinformatics and The Open Magnetic Resonance Journal (Bentham Science Publishers, The Netherlands and USA), and Protein Expression and Purification. Besides, I have been reviewing several National Journals too.

 

vii.     Editorial Advisory Board Member:

 

Member, Editorial Board, of “The Open Magnetic Resonance Journal”, “The Open Applied Informatics Journal”, and “Current Bioinformatics”, launched by Bentham Science Publishers, The Netherlands and U.S.A., 2005-Till date.

 

viii.    Invited Speaker at International Conferences

 

Invited to speak at various national and international conferences and work-shops. To name a few: Invited Speaker at the XX, XXI, XXII, XXIII, XXIV and XXV International Conference on Magnetic Resonance in Biological Systems (ICMRBS) held biannually at Toronto (Canada; 2002), Hyderabad (India; 2005), Gottingen (Germany; 2006), San Diago (USA; 2008) and Cairns (Australia; 2010); and to be held at Lyon (France; 2012), respectively. Invited speaker at the 16th and 17th Triennial Conference for the International Society of Magnetic Resonance (ISMAR) held in Taiwan (October 14-19, 2007) and in Florence (July 3-9, 2010), respectively.

                       One of the faculty at the International Workshop on "High throughput NMR structure determination of proteins and peptides in the post-genomic era", held in Academia Sinica, Taipei, Taiwan held during Nov 1-2, 2003, the IUPAB and JASS sponsored (JASS-2004) Winter School on NMR Spectroscopy at the Frontier of Progress in the Life Sciences held at the Institute for Protein Research, Osaka University, Suita, Osaka, Japan, held during January 19 to 31, 2004.

                       Invited Speaker at the International Union for Pure and Applied Biophysics (IUPAB) sponsored workshop on “Education and Capacity Building in Biophysics” held at IIT Roorkee, as an invited speaker, (February 24-25, 2002). 

                       Invited speaker at the Workshop on “Structural Biology”, organized jointly by “Indian National Science Academy” and “Chineese Science Academy”, held at IISc, Bangalore, (December 21-22, 2007). Invited speaker at the International (WWNMR) Workshop on "Recent Advances in NMR Methods", held in Beijing, China (October 30, 2011).

                       Regular invited speaker at National Magnetic Resonance Society (NMRS) and Indian Biophysical Society (IBS) Symposia and the meetings of Indian Science Congress Association (ISCA).

             

              Invited to educate the post-graduate teachers and researchers on NMR spectroscopy during various National Work-Shops held under Continuing Education Programs/Faculty Refresher Courses

 

ix.      Academic Training Imparted:

 

Ph.D. Students trained:

Besides, Prof. Chary has been guiding summer students under the TIFR Visiting Student Research Program and students sponsored by Indian Academy of Sciences, Bangalore.

Post-doctoral Fellows trained:

 

 

 

 

 

x.       Assistance rendered to “DCS” and “Molecular Biophysics Group”

 

 

xi.      Assistance rendered to “National Facility for High Field NMR”

 

Prof. Chary to assist National Facility for High field NMR in its day-to-day activities. He is the Co-PI of the Facility. Celebrating my 29th year of association with it.

 

xii.     Examiner and Reviewer

 

I have been an examiner of several Ph.D., theses and reviewer of several BRNS, DST, CSIR and DBT project proposals.

 

xiii.    Assistance to other Institutions

 

 

xiv.    Assistance rendered to the TIFR committees:

 

 

xiv.  Non-DAE Projects:

      

       Marie Curie International Research Staff Exchange Scheme: Call identifier: FP7-PEOPLE-2009-IRSES (WW-NMR) under the Seventh Framework Programme of European Union.