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NEW LAB, Starting in September 2019 !        

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Protein quality control and intercellular communication

 

Living cells have evolved with intricate protein quality control machinery, that not only ensures formation of functional three-dimensional structure of proteins, but also eliminates the cytotoxic protein aggregates. This quality control mechanism, however, fails to respond in disease conditions like Alzheimer's disease, Parkinson's disease, type-2 diabetes, some types of cancer etc. Many such protein misfolding diseases are associated with the abnormal intercellular communication, where synchronization of overall body function is disrupted. Under the normal condition, this intercellular communication is primarily mediated through the chemical messengers like, hormones, neurotransmitters, proteins etc. Our laboratory aims to understand:

(1) Molecular mechanism of intercellular communication, in normal and pathological conditions.

(2) Role of protein quality control machinery in producing functional and non-functional protein structures inside the cell.

For detail projects, please visit the "Research" section.

Updates !

Lab vacancy:

PhD / M.Sc. student position: background in biochemistry / biophysics / cell biology. Selection through TIFR Graduate Students admission program.

Post-doctoral fellow position: background in cell biology / biochemistry, with experience in microscopy. For details about the projects and possibilities, please contact Debasis (debasis_2u@yahoo.com), with CV and publications.