Tata Institute of Fundamental Research

Blog

Gotam K Jarori

Professor

Structure-activity relationship (SAR) in proteins


Biochemistry, Biophysics, Molecular Biology

Living cells are a complex chemical machine where almost all functions are performed by proteins. Understanding the biochemical and biological function(s) of these molecules and correlating these to their structure, is the prime objective of our research. Currently we are investigating some of the proteins from P. falciparum with an objective to understand basic parasite biology and to identify novel drug and vaccine targets against malaria. One such protein is 'enolase', a glycolytic enzyme. Our studies show that this protein is present on cell surface, nucleus, cytosol and associate with food vacuole and cytoskeletal structures. Our efforts at present are focused on understanding the novel biological functions that enolase may have in parasite nucleus, food vacuole and cell membrane.


Selected Publications

Mout R, Xu ZD, Wolf AK, Davisson VJ, Jarori GK (2012) Anti-malarial activity of geldanamycin derivatives in mice infected with Plasmodium yoelii. Malaria Journal 11: 54

Das S, Shevade S, LaCount DJ, Jarori GK (2011) Plasmodium falciparum enolase complements yeast enolase functions and associates with the parasite food vacuole. Molecular and Biochemical Parasitology 179: 8

Vora HK, Shaik FR, Pal-Bhowmick I, Mout R, Jarori GK (2009) Effect of deletion of a plant like pentapeptide insert on kinetic, structural and immunological properties of Enolase from Plasmodium falciparum. Archives of Biochemistry and Biophysics 485: 128

Pal-Bhowmick I, Mehta M, Coppens I, Sharma S, Jarori GK (2007) Protective properties of Plasmodium falciparum Enolase. Infection & Immunity 75: 5500

Pal-Bhowmick I, Vora HK, Jarori GK (2007) Sub-cellular localization and post-translational modifications of the Plasmodium yoelli enolase suggest moonlighting functions. Malaria Journal 6: 45

Pal-Bhowmick I, Sadagopan K, Jarori GK (2007) Differential susceptibilities of Plasmodium falciparum vs yeast and mammalian enolases for dissociation into active monomers. FEBS Journal 274: 1932

Pal-Bhowmick I, Sadagopan K, Vora HK, Sehgal A, Sharma S, Jarori GK (2004) Cloning, over-expression, purification and characterization of Plasmodium falciparum enolase. European Journal of Biochemistry 271: 4545

Contact

  • Room B-301
  • Tel: +91 22 2278 2228
  • gkj @ tifr.res.in
  • Webpage