Tata Institute of Fundamental Research

Blog

Himanshu Sinha

Reader

Finding the molecular basis of quantitative traits


Genetics, Genomics

In nature, most individuals vary by small degree, rather than descrete differences. For example, human height varies by degree not by presence or absence of height. Similarly, we see variation in skin and eye colour, susceptibility to several diseases such as diabetes, cancers, cardiac disorders. This kind of variation is brought about by multiple interacting genes and these characters are called quantitative traits. However, dissection of the genetic factors determining quantitative traits is difficult because of the multiple causal genes, each of which can contribute varying amounts to the character. Recent advances in molecular genetics and biology have provided methods to identify genes involved in these complex traits at a very high resolution. Yeast has become an excellent model system to study these traits at high resolution. We use yeast as a model to address some of the basic questions and fundamental genetic principles governing these traits.

Publications

Tomar P, Sinha H (2014) Conservation of PHO pathway in ascomycetes and role of Pho84. Journal of Biosciences (in press)

Bhatia A, Yadav A, Zhu C, Gagneur J, Radhakrishnan A, Steinmetz L, Bhanot G, Sinha H (2014) Yeast growth plasticity is regulated by environment specific multi-QTL interactions. G3: Genes, Genomes, Genetics doi: 10.1534/g3.113.009142 (in press)

Tomar P, Bhatia A, Ramdas S, Diao L, Bhanot G, Sinha H (2013) Sporulation genes associated with sporulation efficiency in natural isolates of yeast. PLoS ONE 8: e69765

Fraser HB, Levy S, Chavan A, Shah HB, Perez JC, Zhou Y, Siegal ML, Sinha H (2012) Polygenic cis-regulatory adaptation in the evolution of yeast pathogenicity. Genome Research 22: 1930

Gagnuer J, Sinha H, Perocchi F, Bourgon R, Huber W, Steinmetz LM (2009) Genome-wide allele- and strand-specific expression profiling. Molecular Systems Biology 5: 274

Sinha H, David L, Pascon RC, Clauder-Muenster S, Krishnakumar S, Nguyen M, Shi G, Dean J, Davis RW, Oefner PJ, McCusker JH, Steinmetz LM (2008) Sequential elimination of major-effect contributors identifies additional quantitative trait loci conditioning high-temperature growth in yeast. Genetics 180: 1661

Sinha H, Nicholson BP, Steinmetz LM, McCusker JH (2006) Complex genetic interactions in a quantitative trait locus. PLoS Genetics 2: e13

Steinmetz LM, Sinha H, Richards DR, Spiegelman JI, Oefner PJ, McCusker JH, Davis RW (2002) Dissecting the architecture of a quantitative trait locus in yeast. Nature 416: 326

Contact

  • Room B-208
  • Tel: +91 22 2278 2827
  • hsinha @ tifr.res.in
  • Webpage