Tata Institute of Fundamental Research

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Mahendra Sonawane

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Genetic analysis of epidermal cell adhesion in the developing zebrafish


Cell Biology

We use zebrafish as a model organism to investigate the developmental and cellular mechanisms involved in the establishment as well as maintenance of the epidermal architecture and integrity. We combine genetic approaches with confocal microscopy to unravel the importance of cell size, cell shape, cell polarization and cell adhesion in epidermal morphogenesis. In addition, we are interested in understanding how the changes in cell size or cell-polarity lead to re-calibration of tissue homeostasis or to epidermal hyperplasia.


Selected Publications

Nagendran M, Arora P, Gori P, Mulay A, Ray S, Jacob T, Sonawane M (2015) Canonical Wnt signalling regulates epithelial patterning by modulating levels of laminins in zebrafish appendages. Development 142: 320

Sonal, Sidhaye J, Phatak M, Banerjee S, Mulay A, Deshpande O, Bhide S, Jacob T, Gehring I, Nuesslein-Volhard C, Sonawane M (2014) Myosin Vb mediated plasma membrane homeostasis regulates peridermal cell size and maintains tissue homeostasis in the zebrafish epidermis. PLoS Genetics 10: e1004614

Chen YY, Harris MP, Levesque MP, Nuesslein-Volhard, C and Sonawane M (2012) Heterogeneity across the dorso-ventral axis in zebrafish EVL is regulated by a novel module consisting of sox, snail 1a and max genes, Mechanisms of Development 129: 12-23

Reischauer S, Levesque M, Nuesslein-Volhard C, Sonawane M (2009) Lgl2 executes its tumor suppressor function by regulating ErbB signaling in zebrafish epidermis. PLoS Genetics 5: e1000720

Sonawane M, Martin-Maischein H, Schwarz H, Nuesslein-Volhard C (2009) Lgl2 and E-cadherin act antagonistically to regulate hemidesmosome formation during epidermal development in zebrafish. Development 136: 1231

Sonawane M, Carpio Y, Geisler R, Schwarz H, Maischein HM, Nuesslein-Volhard C (2005) Zebrafish penner/lethal giant larvae 2 functions in hemidesmosome formation, maintenance of cellular morphology and growth regulation in the developing basal epidermis. Development 132: 3255

Contact

  • Room B230 (Mumbai), CML Building (NCRA Pune)
  • Extn. 2707
  • mahendras @ tifr.res.in
  • Webpage