Tata Institute of Fundamental Research

Blog

Shubha Tole

Professor

Genetic mechanisms and signaling pathways in the developing brain


Neurobiology

Cerebral cortex and the amygdala are the two most complex brain structures. The cortex is responsible for higher brain functions- perception, language, learning, memory; the amygdala is the "emotion center" of the brain. The broad interests of our group are in the genetic mechanisms that control the formation of these highly specialized structures. We use "knockout" and RNAi approaches, in-utero perturbation techniques, and tissue culture perturbations. We also generate transgenic mouse embryos using genetically engineered embryonic stem cells (ES cells). We analyze these by in situ hybridization, immunohistochemistry, and labelled nerve tract tracing. Some projects in the lab use Drosophila genetics or standard biochemistry to understand interactions between different molecular players.


Selected Publications

Huilgol D, Udin, S, Shimogori T, Saha B, Roy A, Aizawa S, Hevner RF, Meyer G, Ohshima T, Pleasure SJ, Zhao Y, Tole S (2013) Dual origins of the mammalian accessory olfactory bulb revealed by an evolutionarily conserved migratory stream. Nature Neuroscience 16: 157

Roy A, Gonzalez M, Pierani A, Meyer G, Tole S (2013) Lhx2 regulates the development of the forebrain hem system. Cerebral Cortex doi:10.1093/cercor/bhs421

Roy A, De Melo J, Chaturvedi D, Thien T, Cabrera-Soccoro A, Houart C, Meyer G, Blackshaw S, Tole S (2013) Lhx2 is necessary for themaintenance of optic identity and progression of optic morphogenesis. Journal of Neuroscience 33: 6877

Subramanian L, Sarkar A, Shetty AS, Muralidharan B, Padmanabhan H, Piper M, Monuki ES, Bach I, Gronostajski RM, Richards LJ, Tole S (2011) Lhx2 is necessary and sufficient for regulating the neuron-astrocyte cell fate decision in the developing hippocampus. Proceedings of the National Academy of Sciences USA 108: E265

Mangala VS, Hirokawa KE, Satyaki PRV, Gokulchandran N, Chikbire S, Subramanian L, Shetty AS, Martynoga B, Paul J, Mai MV, Li Y, Flanagan LA, Tole S, Monuki ES (2008) Lhx2 selector activity specifies cortical identity and suppresses hippocampal organizer fate. Science 319: 304

Hari P, Deshpande M, Sharma N, Rajyadhaksha N, Ramkumar N, Kimura K, Rodrigues V, Tole S (2008) Chip is required for post-eclosion behaviour in Drosophila. Journal of Neuroscience 28: 9145

Remedios R, Huilgol D, Saha B, Hari P, Bhatnagar L, Ohshima T, Stoykova A, Tole S (2007) A novel stream of amygdaloid cells from the caudal telencephalon reveals a developmental link between the amygdala and the neocortex. Nature Neuroscience 10: 1141

Lakhina V, Falnikar A, Bhatnagar L, Tole S (2007) Early thalamocortical tract guidance and topographic sorting of thalamic projections requires LIM-homeodomain gene Lhx2. Developmental Biology 306: 703

Saha B, Hari P, Huilgol D, Tole S (2007) Dual role for LIM-HD gene Lhx2 in the formation of the lateral olfactory tract (LOT). Journal of Neuroscience 27: 2290

Contact

  • Room B-304
  • Tel: +91 22 2278 2878
  • shubhatole @ gmail.com
  • Webpage