Tata Institute of Fundamental Research


Ullas S Kolthur

Associate Professor

Sirtuins: implications in cancer and aging

Biochemistry, Biophysics, Molecular Biology

Metabolic and energy homeostasis play a vital role in governing the cellular pathways. It is important to note that molecular factors involved in these processes are implicated in life-style disorders (diabetes/ obesity), aging and age related diseases (cancer/ neurodegeneration).

One of the proteins that directly link metabolic inputs to various molecular events within a cell is Sir2, which was initially identified in yeast as an NAD-dependent HDAC. Sirutins (Sir2-like proteins) play a vital role in cell survival, DNA damage response, cellular differentiation and aging. We use flies, mice and cell culture systems to elucidate the molecular mechanisms regulated by sirtuins. Importantly, we investigate their functions in metabolic and energy homeostasis and also study their role during aging and age-related diseases such as cancer, diabetes and obesity.


Selected Publications:

Ghosh S, Banerjee K, Vaidya V*, Kolthur-Seetharam U*. (2016-In Press) Early stress history alters serum IGF1 and impairs muscle mitochondrial function in adult male rats. Journal of Neuroendocrinology. In Press

Ho L, Titus AS, Banerjee KK, George S, Lin W, Deota S, Saha AK, Nakamura K, Gut P, Verdin E*, Kolthur-Seetharam U*. (2013) SIRT4 regulates ATP homeostasis and mediates a retrograde signaling via AMPK. Aging.  5(11):835-49

Banerjee KK, Ayyub C, Sengupta S, Kolthur-Seetharam U. (2013) Fatbody dSir2 regulates muscle mitochondrial physiology and energy homeostasis via fat metabolism and IIS, and mimics the autonomous functions of dSir2 in muscles. Mol Cell Biol. 33(2):252-64

Banerjee KK, Ayyub C, Ali SZ Mandot V, Prasad NG, Kolthur-Seetharam U (2012) dSir2 in the fatbody but not muscles regulates diet-dependent lifespan extension. Cell Reports (Cell Press) 2(6):1485-91 {The article was previewed in the same issue by Eric Verdin and David Sinclair]

Pubmed: Ullas Kolthur-Seetharam
Pubmed: Kolthur US
Pubmed: Ullas KS


Awards: Swarnajayanti Award/Fellow, DST-India


  • Room B-306
  • Tel: +91 22 2278 2721
  • ullas @ tifr.res.in
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