Neurobiology of emotion
Life experiences have a profound impact on the brain. Our lab is interested in (1) understanding the neurocircuitry of emotion, (2) its modulation by experience and (3) the alterations in emotional neurocircuitry that underlie complex psychiatric disorders like depression. Using animal models of depression, some of which are based on perturbations of early life experience, we study the molecular, epigenetic and cellular changes that contribute to persistent alterations in behavior. We also study the molecular and cellular adaptations that arise from sustained antidepressant treatment. One such adaptation is the regulation of adult neural stem cells and we are interested in the pathways that regulate adult neurogenesis and their contribution to depression-related behavior. Our lab uses pharmacological and genetic approaches, and tools such as microarrays, in situ hybridization, immunohistochemistry and behavioral tests to understand the neurocircuitry of emotion.
Sarkar A, Chachra P, Kennedy P, Pena CJ, Desouza LA, Nestler EJ, Vaidya VA (2014) Hippocampal HDAC4 Contributes to Postnatal Fluoxetine-Evoked Depression-Like Behavior. Neuropsychopharmacology. doi: 10.1038/npp.2014.73
Sarkar A, Chachra P, Vaidya VA (2013) Postnatal Fluoxetine-Evoked Anxiety Is Prevented by Concomitant 5-HT2A/C Receptor Blockade and Mimicked by Postnatal 5-HT2A/C Receptor Stimulation. Biological Psychiatry doi: 10.1016/j.biopsych.2013.11.005
Suri D, Veenit V, Sarkar A, Thiagarajan D, Kumar A, Nestler EJ, Galande S, Vaidya VA (2013) Early stress evokes age-dependent biphasic changes in hippocampal neurogenesis, Bdnf expression and cognition. Biological Psychiatry 73: 658
Benekareddy M, Vadodaria KV, Nair AR, Vaidya VA (2011) Postnatal 5-HT2 receptor blockade prevents the emergence of anxiety behavior, dysregulated stress-induced immediate early gene responses and specific transcriptional changes that arise following early life stress. Biological Psychiatry 70: 1024
Benekareddy M#, Goodfellow NM#, Lambe EK*, Vaidya VA* (2010) Enhanced function of prefrontal serotonin 5-HT2 receptors in a rat model of psychiatric vulnerability. Journal of Neuroscience 30: 12138 (#equal first authors, *equal senior authors)
Yanpallewar SU, Fernandes K, Marathe SV, Vadodaria KC, Jhaveri D, Rommelfanger K, Ladiwala U, Jha S, Muthig V, Hein L, Bartlett P, Weinshenker D, Vaidya VA (2010) α2-adrenoceptor blockade accelerates the neurogenic, neurotrophic, and behavioral effects of chronic antidepressant treatment. Journal of Neuroscience 30: 1096.