Zebrafish Epidermis Research Laboratory

Research

 
  • <i>goosepimple</i> mutant showing balling up pf epidermal cells, Sonal, Sidhaye <i>et al</i> 2014
  • Basal epidermis in the fin fold showing cell shapes pattern and nuclear beta catenin gradient(red) and nucleus marked with DAPI(blue)
  • MyoVB morphant showing presence of low pH compartments, Sonal, Sidhaye <i>et al</i> 2014
  • Phaloidin marking the actin microrideges in Tubingen 6dpf
 

Plasma membrane homeostasis in cell size regulation and epidermal homeostasis

In a forward mutagenesis screens two loci, goosepimples (gsp) and romeharsha (rhs), were identified as having a non-lethal embryonic phenotype characterized by small and rounded up cells in the periderm (van Eeden et al., 1996; Sonawane and Volhard, unpublished)...

Cell shape regulation in the median fin fold epithelium

The median fin fold in zebrafish larvae is an unpaired appendage formed of an epithelial (epidermal) fold and mesenchyme. It has been used as a paradigm to study the role of extra-cellular matrix components in tissue morphogenesis (Carney et al., 2010; van Eeden et al., 1996)...

Cell polarity regulators in the maintenance of epidermal architecture

In monolayered epithelia, apical basal polarity is established and maintained by four major pathways. Two of these viz., Par3-aPKC and Crumbs-Stardust function in the apical domain whereas Lgl-Dlg- Scrib and Yurt-Coracle are mostly basolateral regulators (Martin-Belmonte and Mostov, 2008; Laprise and Tepass, 2011)...