Molecular Mechanisms of Cell Division

Research Focus

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Our group is interested in understanding the mechanism underlying the process of cell division and its regulation. We use a combination of in vitro and in vivo approaches including genetic, cellular, molecular and mathematical approaches to understand the assembly and function of the cell division apparatus. We use the fission yeast as a simple model system to carry out most of our studies. As the process of cytokinesis and its regulation is mechanistically conserved, our findings should be applicable to understanding how cell division is controlled in human cells. Failure to complete cytokinesis results in aneuploidy associated with infertility, developmental defects and genetic instability that often lead to cancer. Hence, studying cytokinesis has important implications for cell proliferation and differentiation in normal development and also in disease conditions.

  • Cytokinesis in Fission Yeast cells.