School of Natural Sciences
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Rational Design of an Artificial Peroxidase
We have rationally modified the active site of this thermostable P450 to introduce a residue at the distal heme pocket that could act as an acid-base catalyst and thus enhance the peroxidase activity in the mutant enzyme. This could potentially lead to the creation of a thermally stable artificial peroxidase...
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Structure/Dynamics of Proteins and Fibrils from Solid State NMR
Nuclear magnetic resonance spectroscopy of solid materials reveals structural and dynamics information. The methods make use of a combination of sample preparation, radiofrequency pulse sequence design, acquisition of multi-dimensional spectra techniques to get geometry information and structural elucidation…..
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Proteins and the Computational Microscope
Theoretical modeling along with high performance computational simulations of biomolecules are probing how thermal motions of atoms drive diverse molecular scale processes such as charge transfer, enzymatic catalysis, biomolecular aggregation…..
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Tracking the molecular players in neurodegenerative disorders
In the department of chemical sciences, we investigate biophysically tractable yet biologically interesting systems, using (mostly) spectroscopic and imaging tools, most of which we build ourselves. Our recent focus has been on two problems: protein misfolding/aggregation, and vesicular neurotransmission....
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Single-Molecule Protein Mechanics
Single-molecule techniques are novel approaches to understand the structure-stability-function relationship of proteins, especially force spectroscopy methods in studying mechanically relevant proteins. These techniques are also useful to drive chemical reactions and bond-breakage at single-molecule/bond level to understand the reaction mechanism and get the elusive ‘transition state’ properties....
About the Department
Scientists at the DCS explore the link between living systems and the physical laws that govern nature. They study molecules ranging in size as small as water and as large as a virus. The laws that govern interaction in molecules are best studied in well-defined and isolated small molecules. This information becomes applicable to design novel materials with exotic properties, of value to chemical and solar energy industries and to medical applications. To understand working of biological systems, studies are made on structure, dynamics and function of biological molecules. TIFR is a leader in state-of-the-art experimental techniques such as high field NMR, ultrafast lasers and single molecule methodologies.
News & events
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Prof. R.V. Hosur elected as Fellow of ISMAR
Prof. Ramakrishna V. Hosur has been elected as a 'FELLOW' of the International Society of Magnetic Resonance in recognition of distinction in contributing to the field of magnetic resonance.
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Special Course on Allostery by Prof. Amnon Horovitz
Prof. Amnon Horovitz from the Weizmann Institute of Science will be conducting a three day course on "Allosteric Models in Biology"
Dates: Monday 23, Tuesday 24, Wednesday 25 January 2016
Where: AG-80
Lecture Timings: 11:30 am to 1:00 pm
Please click here for the course syllabus.
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Awards for Vivek Polshettiwar`s research group
Mr. Rustam Singh received best poster award in 4th International Conference on Advanced Nanomaterial and Nanotechnology (ICANN-2015), one of the best nano-conference in India, organized by IIT, Guwahati during Dec 8-11, 2015.
Mr. Rustam Singh received best poster award in ICONSAT 2016 organized by IISER, Pune and DST, Nanomission. He presented his recent work on, "TiO2 coated KCC-1 for photocatalysis: Nanoparticle formation and quantum confinement".
Dr. Polshettiwar is recognized as one of the 'Emerging Investigators 2016' for Novel design strategies for new functional materials by Journal of Materials Chemistry A of Royal Society of Chemistry, UK.
Dr. Polshettiwar has been awarded prestigious "Bronze Medal" by Chemical Research Society of India (CRSI) for 2017.
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Awards for Jyotishman Dasgupta's Research Group
Ms Ankita Das won the best poster prize in the recently concluded Symposium on Advanced Bio-inorganic Chemistry (SABIC 2017) meeting in Kolkata during January 7-11th 2017. Her poster was titled: "Visible light induced C-H bond activation inside a water soluble nanocage"
Mr. Palas Roy won the best poster award in DCS Annual meeting 2016 which took place in TIFR Colaba during December 19th to 21st 2016. The poster was titled: "Tracking Singlet Fission in Semiconducting Organic Nanoparticles"
Ms. Ankita Das got Best Poster Award for her poster titled "Probing Dynamic Water Interaction with Molecular Nanocages Using Host-Guest Charge Transfer States" in the 2016 Ultrafast Science (UFS) theme meeting held in BARC Mumbai from 24th to 26th of November 2016
Ms. Melby Johny got poster award for his poster titled "Tracking the photo-induced vesicle-to-fibril transition of H-Azo-Phe-Phe-OH in solution" in the 14th Optics Within Life Sciences (OWLS) meeting held in Mumbai during March 16th-19th 2016.
Calendar
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August 28, 2017 at 4.00 pm in AG-69
Seminar by Prof. Amitabha Chattopadhyay, Centre for Cellular and Molecular Biology, Hyderabad
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August 10, 2017 at 4.00 pm in AG-80
Seminar by Dr. Somrita Mondal, Indian Institute of Science Education and Research, Mohali
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August 3, 2017 at 4.00 pm in AG-80
Seminar by Dr. Kalyan Chakrabarti, Max Planck Institute for Biophysical Chemistry, Germany
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August 2, 2017 at 11.30 a.m.in AG-80
Seminar by Dr. Kalyan Chakrabarti, Max Planck Institute for Biophysical Chemistry, Germany