TIFR
Department of Chemical Sciences
School of Natural Sciences
  • Rational Design of an Artificial Peroxidase

    We have rationally modified the active site of this thermostable P450 to introduce a residue at the distal heme pocket that could act as an acid-base catalyst and thus enhance the peroxidase activity in the mutant enzyme. This could potentially lead to the creation of a thermally stable artificial peroxidase...

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  • Structure/Dynamics of Proteins and Fibrils from Solid State NMR

    Nuclear magnetic resonance spectroscopy of solid materials reveals structural and dynamics information. The methods make use of a combination of sample preparation, radiofrequency pulse sequence design, acquisition of multi-dimensional spectra techniques to get geometry information and structural elucidation…..

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  • Turn-on Sensors for in vivo Imaging

    The quest for unraveling fundamental biological pathways relies heavily upon the ability to precisely visualize strategic molecular players in vivo. Our group works at the interface of synthetic chemistry, molecular biology, and imaging, to develop molecular probes which give a specific ‘ON’ response only in presence of the bio-molecule of interest....

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  • Supersonic Jet Spectroscopy of Weak H-bonds

    Supersonic Jet Spectroscopy of molecular clusters is being used to investigate weak non-covalent interactions. Such forces play important roles in imparting structures to various biopolymers and also enable them to carry out many functions in living organisms under ordinary conditions that keep the biological systems ticking....

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  • Chemistry driven by delocalized molecular motions

    Chemical reactions are often conceptualized by making and breaking one bond at a time. The idea of localized bond alterations inhibits intuitive thinking about the structure as a whole. The Dasgupta group is focusing on creating a theme using collective motions existing in the molecular structure to drive selective and efficient chemistry...

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About the Department

Scientists at the DCS explore the link between living systems and the physical laws that govern nature. They study molecules ranging in size as small as water and as large as a virus. The laws that govern interaction in molecules are best studied in well-defined and isolated small molecules. This information becomes applicable to design novel materials with exotic properties, of value to chemical and solar energy industries and to medical applications. To understand working of biological systems, studies are made on structure, dynamics and function of biological molecules. TIFR is a leader in state-of-the-art experimental techniques such as high field NMR, ultrafast lasers and single molecule methodologies.

News & events

  • RSC article on Vivek Polshettiwar
    Vivek comes from Saudi Arabia where he was an Ass. Professor/Sr. Scientist at the Catalysis Center, KAUST, Thuwal, KSA.
  • Honors for Vivek Polshettiwar
    Vivek comes from Saudi Arabia where he was an Ass. Professor/Sr. Scientist at the Catalysis Center, KAUST, Thuwal, KSA.
  • Prof. R.V. Hosur awarded "Padmashree"

    One of our colleagues, Prof. R.V. Hosur has been awarded "Padmashree" by the Government of India. Prof. Hosur is currently the Senior Professor in the Department. He is also been holding the position of the Director at the Centre for Excellence in Basic Sciences at Kalina, Mumbai

  • Technological innovation from Maiti group
    Prof. Sudipta Maiti`s research group has made significant contributions to the development of biophotonic instrumentation and methodology.

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