Department of Chemical Sciences
School of Natural Sciences

K. V. R. Chary

K. V. R. Chary
Senior Professor
Department of Chemical Sciences
NMR-202, Department of Chemical Sciences
Tata Institute of Fundamental Research
Homi Bhabha Road, Colaba
Mumbai, 400 005, India
91 22 2278 2489
91 22 2278 3489 (Res)
91 22 2280 4860 (Res)
91 22 2280 4610
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Academic Profile
Doctoral Degree
1983, Osmania University, Hyderabad, Andhra Pradesh, India.
Postdoctoral Experience
1988-1990, ETH Zurich Switzerland.
  • Current Research
  • Selected Publications

Investigation of the 3D structures and properties of biological molecules, particularly proteins and nucleic acids, in atomic detail and their correlation with biological activity; Protein Engineering; Development of NMR methodologies and algorithms for NMR assignments and 3D structural analysis.

  • R. P. Barnwal, M. K. Jobby, K. M. Devi, Y. Sharma, K. V. R. Chary,* Solution structure and calcium-binding properties of M-crystallin, a primordial βϒ-crystallin from archaea. (2009), J. Mol. Biology, 386, 675-689.
  • S. M. Mustafi, R. B. Mutalik, R. Jain, K. Chandra, A. Bhattacharya and K. V. R. Chary,* Structural characterization of a novel Ca2+-binding protein from Entamoeba histolytica: Structural basis for the observed functional differences with its isoform. (2009), J. Bio. Inorg. Chem., 14, 471-483.
  • Aravind P, Chandra K, Reddy PP, Jeromin A, Chary KVR* and Sharma Y (2008) Regulatory and structural EF-hand motifs of neuronal calcium sensor-1: Mg2+ modulates Ca2+-binding, Ca2+-induced conformational dynamics and equilibrium unfolding transitions, J. Mol. Biology 376 1100-15.
  • Barnwal RP, Atreya HS*, Chary KVR* (2008) Chemical shift based editing of CH3 groups in fractionally 13C-labelled proteins using GFT (3, 2)D CT-HCCH-COSY: stereospecific assignments of CH3 groups of Val and Leu residues., J Biomol NMR 42 149-54.
  • Barnwal RP, Ashok K. Rout, H. S. Atrya, Chary KVR* (2008) Identification of C-terminal neighbours of amino acid residues without an aliphatic 13Cϒ as an aid to NMR assignments in proteins. J Biomol NMR 4 191-7.
  • Barnwal RP, Rout AK, Chary KVR* and Atreya HS, (2008) Rapid Measurement of pseudocontact shifts in paramagentic proteins by GFT NMR spectroscopy., The Open Magnetic Resonance Journal 1 16-28.
  • Rapid measurement of 3J(HN-Hα) and 3J(N-Hβ) coupling constants in polypeptides. (2007), R. P. Barnwal, Ashok K. Rout, K. V. R. Chary* and H. S. Atreya, J. Biomol. NMR, 39(4), 259-63.
  • S. M. Mustafi, S. Mukherjee, K. V. R. Chary*, Cristina Del Bianco and Claudio Luchinat (2004) Energetics and mechanism of Ca2+ displacement by lanthanides in a calcium binding protein., Biochemistry, 43, 9320-9331.
  • Rani Parvathy.V., Sukesh R. Bhaumik, K. V. R. Chary*, G. Govil, Keliang Liu, Frank B. Howard and H. Todd Miles, NMR Structure of a parallel stranded DNA duplex at atomic resolution. (2002), Nucleic Acids Res., 30, 1500-1511
  • H.S. Atreya, S. C. Sahu, A. Bhattacharya, K. V. R. Chary* and G. Govil, NMR derived solution structure of an EF-hand Calcium binding protein from Entamoeba histolytica. (2001), Biochemistry 40, 14392-14403.
  • H. S. Atreya and K. V. R. Chary,* Selective ‘unlabeling’ of amino acids in fractionally 13C labeled proteins: An approach for stereospecific NMR assignments of CH3 groups in Val and Leu residues. (2001), J. Biomol. NMR., 19, 267-272.
  • H. S. Atreya, S. C. Sahu, K. V. R. Chary,* and G. Govil, A Tracked AuTomated Assignments in PROteins (TATAPRO). (2000), J. Biomol. NMR., 17, 125-136.
  • Mahua Ghosh, N. Vinay Kumar, Umesh Varshney and K. V. R. Chary*, Structural basis for Uracil DNA glycosylase interaction with uracil: NMR study. (2000), Nucleic Acids Res., 28, 1906-1912.
  • S. C. Sahu, A. Bhattacharya, K. V. R. Chary,* and G. Govil, Secondary structure of a calcium binding protein (CaBP) from Entamoeba histolytic. (1999), FEBS Letters., 459, 51-56.
  • Karthikeyan G, K. V. R. Chary* and Basuthkar J Rao, Fold-back structures at distal end influence DNA slippage at proximal end during mononucleotide repeat expansions. (1999), Nucleic Acids Res., 27, 3851-3858.
  • S. R. Baumik, K. V. R. Chary*, G. Govil, L. Keliang, and H.T. Miles, NMR characterization of a triple-stranded complex formed by homo-purine and homo-pyrimidine DNA strands at 1:1 molar ratio and acidic pH. (1995), Nucleic Acids Res., 23, 4116-4121.
  • K. V. R. Chary*, V.K. Rastogi, & G. Govil, An Efficient 2D NMR Technique HELCO for Heteronuclear [31P-1H] Longrange Correlation. (1993), J. Magn. Reson., B 102, 81-83.
  • K. V. R. Chary*, G. Otting and K. Wuthrich, Mesurement of small heteronuclear 1H-15N coupling constants in 15N labelled proteins by 3D HNNHAB–COSY. (1991), J. Magn. Reson., 93, 218-224.
  • K. V. R. Chary* and Sandeep Modi, Analysis of intrasugar interproton NOESY cross-peaks as an aid to determine sugar geometries in DNA fragments. (1988), FEBS Lett., 233, 319-325.
  • K. V. R. Chary*, R.V. Hosur, Tan zu-kun, G. Govil and H.T. Miles, Novel solution conformation of DNA observed in d-GAATTCGAATTC by 2D NMR. (1987), Biochemistry, 26, 1315-1322.