Department of Chemical Sciences
School of Natural Sciences

October 26, 2015 at 4.00 pm in AG-69

Title :

Molecular Probes and Templates for DNA Structures

Abstract :

DNA exists in variety of structural forms supported by canonical (A, B and Z-DNA) and non-canonical [H-DNA, G-quadruplex, i-motif, A-motif etc] hydrogen bonding interactions. Small molecules play key role in the study of DNA structures, biological significance, and to treat diseases related to their structure and function. On the other hand, the unique molecular recognition, persistence length and size of DNA inspire researchers to create novel molecular architectures for numerous applications. In this context, we have been developing mutually templated novel small molecule-ss DNA architectures using canonical and non-canonical hydrogen bonding interactions of nucleobases. In this talk, I shall present our recent results on fluorescence probes and nucleobase conjugates to study canonical and non-canonical hydrogen bonded DNA structures as well as to create hybrid DNA ensembles for applications ranging from biology to materials science.




1.    J. Choi and T. Majima, Chem. Soc. Rev. 2011, 40, 5893; A. Rich, D. R. Davies, F. H. C. Crick and J. D. Watson, J. Mol. Biol., 1961, 3, 71.

2.    N. Narayanaswamy, M. Kumar, R. Sharma, P. K. Samanta, S. K. Pati, S. K. Dhar, T. K. Kundu and T. Govindaraju, Sci. Rep. 2014, 4, 6476.

3.    N. Narayanaswamy, S. Das, P. K. Samanta, K. Banu, S. K. Dhar, S. K. Pati and T. Govindaraju, Nucleic Acids Res. (2015)DOI: 10.1093/nar/gkv875.

4.    N. Narayanaswamy, M. Unnikrishnan, M. Gupta and T. Govinadaraju. Bioorg. Med. Chem. Lett. 2015, 25, 2395.

5.    M. B. Avinash and T. Govindaraju, Nanoscale2014,6, 13348.

6.    N. Narayanaswamy, G. Suresh, U. D. Priyakumar, and T. Govindaraju, Chem. Comm. 2015, 51, 5493-5496.