TIFR
Department of Chemical Sciences
School of Natural Sciences

August 28, 2017 at 4.00 pm in AG-69

Title :

Dipole Organization and Membrane Biophysics: A Tale of Two Studies

Abstract :

Biological membranes are complex assemblies of lipids and proteins that allow cellular compartmentalization and act as an interface, through which cells communicate with each other and with the external milieu.  In physical terms, membranes can be treated as a complex oriented fluid which is a weakly coupled, non-covalent, and anisotropic assembly of molecules in two-dimensions, and can therefore be treated as soft matter.  

In this lecture, I will focus on the application of red edge excitation shift (REES) and membrane dipole potential to explore organization and dynamics of membrane lipids and proteins. Both these phenomena are dependent on organization of membrane dipoles.

References:

1.Haldar, S., Chaudhuri, A., and Chattopadhyay, A. (2011) J. Phys. Chem. B 115: 5693-5706 (Feature Article).

2.Chattopadhyay, A., and Haldar, S. (2014) “Dynamic Insight into Protein Structure utilizing Red Edge Excitation Shift” Acc. Chem. Res. 47: 12-19.

3.   Haldar, S., Kanaparthi, R.K., Samanta, A., and Chattopadhyay, A. (2012) Biophys. J. 102: 1561-1569. 

4.Lajevardipour, A., Chon, J.W.M., Chattopadhyay, A., and Clayton, A.H.A. (2016) Sci. Rep. 6: 37038. 

 

5.Sarkar, P., Chakraborty, H., and Chattopadhyay, A. (2017) Sci. Rep. 7: 4484.