Research in Systems Biology at TIFR is geared towards probing the effects of chemical and metabolic processes in biological systems at an organism level. NMR spectroscopy of tissue and biofluids collected from animal systems and clinical patients is being used to study the host-parasite interaction during infection by malarial parasites. This is achieved through metabolomics - the newest of all the omics techniques that utilizes multivariate statistical analyses of the spectral data. Such an approach provides the most downstream information on the complex biological networks, as affected by environmental stressors, on a global scale. A more targeted approach using specific labeling strategies of metabolic intermediate followed by spectral profiling using 13C NMR provides information on mechanistic changes during parasitic infection. The global and targeted approach together, provide a holistic physiological picture of the host response and host-parasite interaction.