Research Interests

The major area of research in my group is nuclear magnetic resonance (NMR) and its application to structure, dynamics and interaction of biological macromolecules. In the past, we have worked on lipids and membrane organization, DNA duplexes, triplexes and their specific interaction with proteins. Our present research covers development of NMR pulse sequences, development of software algorithms for NMR data analysis, protein-DNA recognition, structure and dynamics of DNA quadruplexes, protein folding, structure and dynamics of proteins and their complexes with specific substrates/inhibitors. A variety of protein and nucleic acid systems produced synthetically and/ or by gene expression methods are being investigated.

Current Projects

Characterization of GTPase Effector Domain of Dynamin and its Domains

Structural biology & Folding of SUMO Proteins (hSUMO-1, drosophila SUMO) and their Interaction with Ubc9 (E2 enzyme of SUMOylation Pathway)

Folding and Plasticity of HIV-1 protease and its Variants

Study of Dynein and its Interactors

Structural Biology of Malarial Proteins

New NMR pulse sequences and rapid assignments in proteins

Multistranded DNA structure