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At TIFR, research in the area of Biophysics started in 1970 and the emphasis in early years
was on the computational aspects-prediction of structures of molecules on the basis of potential
energies. Over the years, the experimental aspects have grown with the addition of new facilities to
the program. It has become possible to study larger and larger systems making transition from model
system to real systems.
Today, ‘NMR and its applications’ is a strong-hold of the Group. This is augmented by the creation of
facilities for genetic and protein engineering which have enabled production of desired engineered molecules
for detailed investigations on structures, interactions and molecular recognitions.
Following are the broadly classified headings of the current status of NMR based research in area of
macromolecular structural biology/biochemistry:
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| Multidimensional NMR Methods | Protein Folding |
| Structure and Dynamics of Biomolecules | Solid-State NMR |
| Protein-DNA Interactions | In vivo NMR |
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