Glucose acts as a double edged sword on longevity factor SIRT1

Novel discovery from TIFR shows that glucose acts as a double edge sword in regulating the functions of SIRT1. These results have been published in the journal PNAS. The study found that glucose derived cellular metabolite acted as a molecular switch to regulate both the extent and time of activity of the longevity factor, which effected gene expression and regulated metabolic flexibility in the liver. This study has immense therapeutic potential since loss of SIRT1 is associated with obesity and aging, its over-activation resulted in perturbed liver functions, inflammation and a pre-diabetic like state.

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