
Shubha Tole
Professor
Genetic mechanisms and signaling pathways in the developing brain
Neurobiology

Cerebral cortex and the amygdala are the two most complex brain structures. The cortex is responsible for higher brain functions- perception, language, learning, memory; the amygdala is the "emotion center" of the brain. The broad interests of our group are in the genetic and epigenetic mechanisms that control the formation of these highly specialized structures. We use "knockout" and transgenic approaches, in-utero and tissue culture perturbation techniques, ChIP-seq and Mass spectrometry, neurocircuitry tracing and CLARITY-based approaches, and behavioral paradigms to pursue these questions.
Selected Publications
*Kinare V, *Iyer A, Padmanabhan H, Godbole G, Khan T, Khatri Z, Maheshwari U, Bhavana M, Tole S. An evolutionarily conserved Lhx2-Ldb1 interaction regulates the acquisition of hippocampal cell fate and regional identity. In press, Development
Godbole G, Shetty AS, Roy A, D’souza L, Chen B, Miyoshi G, Fishell G, #Tole S (2018) Hierarchical genetic interactions between FOXG1 and LHX2 regulate the formation of the cortical hem in the developing telencephalon. Development 145 doi:10.1242/dev.154583
Bhavana M, Keruzore M, Roy B, Pradhan
S, Shetty AS, Kinare V, D’Souza L, Maheshwari U, Karmodiya K,
Suresh A, Galande S, #Bellefroid
E,
and
#Tole
S (2017b) Dmrt5, a novel neurogenic factor,
reciprocally regulates Lhx2 to control the neuron-glia cell fate
switch in the developing hippocampus.
Journal
of Neuroscience 37(46):11245
Bhavana M, Khatri Z, Maheshwari U,
Gupta R, , Roy B, Pradhan S, Karmodiya K, Padmanabhan H, Shetty
AS,
Balaji CH,
Kolthur U, Macklis JD, Galande S,
and
#Tole S
(2017a). Lhx2 interacts with the NURD
complex and epigenetically modulates cortical neuron subtype
regulators Fezf2 and Sox11
Journal of Neuroscience
2836-16.
PMID: 27909100
Roy A, Gonzalez M, Pierani A, Meyer
G, #Tole S (2014)
Lhx2 regulates the development of the
forebrain hem system
Cerebral Cortex
24(5):1361-72
Shetty AS, Godbole G, Maheshawari U,
Padmanabhan H, Chaudhary R, Muralidharan B, Hou P-S, Monuki
ES, Kuo H-C, V Rema,
#Tole
S (2013) Lhx2 regulates a cortex-specific
mechanism for barrel formation
PNAS
doi:10.1073/pnas.1311158110
Huilgol D, Udin, S, Shimogori T, Saha B, Roy A,
Aizawa S., Hevner RF, Meyer G., Ohshima T, Pleasure SJ, Zhao
Y, #Tole S (2013)Dual
origins of the mammalian accessory olfactory bulb revealed
by an evolutionarily conserved migratory stream
Nature Neuroscience 16(2):157-65
Subramanian L, Sarkar A, Ashwin S, Muralidharan B, Hari
P, Piper M, Monuki ES, Bach I,Gronostajski R, Richards R, and
#Tole, S (2011)Transcription
factor Lhx2is necessary and sufficient to suppress
astrogliogenesis and promote neurogenesis in the developing
hippocampus.PNAS
www.pnas.org/cgi/doi/10.1073/pnas.1101109108
Mangale VS, Hirokawa KE, Satyaki PRV,
GokulchandranN, ChikbireS, Subramanian L, Shetty AS,
Martynoga B, Paul J, Mai MV, Li Y, Flanagan LA,
Tole S#,
and Monuki ES #
(2008) Lhx2
selector activity specifies cortical identity and
suppresses hippocampal organizer fate
Science
319:304-309
# co-corresponding author
“Perspectives” based on this
paper: E. A. Grove “Organizing the Source of Memory”
Science (319) 288-289
A highlight based on this paper: M. H. Flight “Instructions for the Hippocampus” Nature Reviews Neuroscience 9 (3): 164-165
Remedios, R., Huilgol, D., Saha,
B., Hari, P., Bhatnagar, L., Kowalczyk T., Hevner R. F., Suda
Y., Aizawa S., Ohshima, T., Stoykova, A.,
Tole, S#.
(2007) A novel stream of amygdaloid cells from the
caudal telencephalon reveals a developmental link between the
amygdala and the neocortex
Nature Neuroscience
10 (9): 1141–1150
“News and Views” based on this paper:
J. M. Deussing and W. Wurst “Amygdala and Neocortex:
Common Origins and Shared Mechanisms”
Nature Neuroscience 10 (9):
1081-1082
Reviews
Iyer A and Tole S. Neuronal diversity and reciprocal connectivity between the vertebrate hippocampus and septum. Wiley Interdiscip. Rev. Dev. Biol. doi: 10.1002/wdev.370
Chou
S-J and Tole S. Lhx2, an evolutionarily conserved,
multifunctional regulator of forebrain development
Brain Research
pii:
S0006-8993(18)30116-1
Huilgol D and Tole S# (2016) Cell migrations in the developing rodent olfactory system. Cellular and Molecular Life Sciences 73(13), 2467-2490
Editorial:
Tole S. and
Vale, R. (2010). Young leaders for
Biology in India. Science 329: 1441.
(Editorial)
Book Chapter:
Tole
S. and
Hebert J. Telencephalon Patterning. “Cellular Migration
and Formation of Neuronal Connections: Comprehensive
Developmental Neuroscience”
(2013) John Rubenstein and
PaskoRakic (Eds). Academic Press. ISBN:
978-0-12-397265-1
Meeting Report:
Tole S.
and Shashidhara LS (2018)
Gender-sensitization in Indian science:
attitudes and action items” Tole and Shashidhara, 2018, in
press, Current Science
Personal story:
Nature Cell Biology’s “Turning
Points” series: Mentorship comes from many sources.
Tole,
Nature Cell Biology
20:1010 (2018)
Blogs:
https://indiabioscience.org/authors/ShubhaTole
Taking the “ME” out of Mentorship
How to choose which institution or
which lab to join?
One possible plug for the leaky pipeline
Are we doing enough?
How are we viewing collaborations?
Advice for students starting out in
research
Contact
- Room B-304
- Tel: +91 22 2278 2878
- shubhatole @ gmail.com
- Webpage