
Shubha Tole
Professor
Genetic mechanisms and signaling pathways in the developing brain
Neurobiology

Cerebral cortex and the amygdala are the two most complex brain structures. The cortex is responsible for higher brain functions- perception, language, learning, memory; the amygdala is the "emotion center" of the brain. The broad interests of our group are in the genetic and epigenetic mechanisms that control the formation of these highly specialized structures. We use "knockout" and transgenic approaches, in-utero and tissue culture perturbation techniques, ChIP-seq and Mass spectrometry, neurocircuitry tracing and CLARITY-based approaches, and behavioral paradigms to pursue these questions.
Selected Publications
Pal S, Dwivedi D, Pramanik T,
Godbole G, Iwasato T, Jabaudon D, Bhalla US and Tole S,
(2021) An early cortical progenitor-specific mechanism
regulates thalamocortical innervation.
Journal of Neuroscience, 41(32),
6822
*Kinare V, *Iyer A, Padmanabhan H, Godbole G, Khan T, Khatri Z,
Maheshwari U, Bhavana M, Tole S (2020)
An evolutionarily conserved Lhx2-Ldb1
interaction regulates the acquisition of
hippocampal cell fate and regional identity. Development, 147(20)
Godbole
G, Shetty AS, Roy A, D’souza L, Chen B, Miyoshi G,
Fishell G, #Tole
S (2018) Hierarchical genetic
interactions between FOXG1 and LHX2 regulate the formation of
the cortical hem in the developing telencephalon. Development, 145(1)
Bhavana
M, Keruzore M, Roy B, Pradhan S, Shetty AS, Kinare
V, D’Souza L, Maheshwari U, Karmodiya K, Suresh A, Galande
S, #Bellefroid
E, and #Tole
S (2017b) Dmrt5, a novel neurogenic factor,
reciprocally regulates Lhx2 to control the neuron-glia cell fate
switch in the developing hippocampus Journal
of Neuroscience 37(46):11245
Bhavana
M, Khatri Z, Maheshwari U, Gupta R, , Roy B,
Pradhan S, Karmodiya K, Padmanabhan H,
Shetty AS, Balaji CH, Kolthur
U, Macklis JD, Galande S, and
#Tole S
(2017). Lhx2
interacts with the NURD complex and epigenetically modulates
cortical neuron subtype regulators Fezf2 and Sox11
Journal of Neuroscience
2836-16.
PMID: 27909100
Huilgol
D, Udin, S, Shimogori T, Saha B, Roy A, Aizawa S., Hevner RF,
Meyer G., Ohshima T, Pleasure SJ, Zhao Y,
#Tole S
(2013)Dual origins of the
mammalian accessory olfactory bulb revealed by an evolutionarily
conserved migratory stream
Nature Neuroscience 16(2):157-65
Subramanian L, Sarkar
A, Ashwin S, Muralidharan B, Hari P, Piper M, Monuki ES, Bach
I,Gronostajski R, Richards R, and
#Tole, S
(2011)Transcription factor Lhx2is
necessary and sufficient to suppress astrogliogenesis and
promote neurogenesis in the developing hippocampus.
PNAS, 108(27)
E265- E274
Mangale
VS, Hirokawa KE, Satyaki PRV, GokulchandranN, ChikbireS,
Subramanian L, Shetty AS, Martynoga B, Paul J, Mai MV, Li Y,
Flanagan LA, Tole S#, and Monuki ES #
(2008) Lhx2 selector
activity specifies cortical identity and
suppresses hippocampal organizer fate
Science,319:304-309
# corresponding author
“Perspectives” based on
this paper: E. A. Grove “Organizing the
Source of Memory” Science (319)
288-289
A highlight based on
this paper: M. H. Flight “Instructions for
the Hippocampus” Nature Reviews
Neuroscience 9 (3): 164-165
Remedios, R., Huilgol,
D., Saha, B., Hari, P., Bhatnagar, L., Kowalczyk T., Hevner R.
F., Suda Y., Aizawa S., Ohshima, T.,
Stoykova, A., Tole, S#.
(2007) A novel stream of amygdaloid cells
from the caudal telencephalon reveals a developmental link
between the amygdala and the neocortex
Nature Neuroscience
10 (9): 1141–1150
“News and Views” based on this paper: J. M. Deussing and W. Wurst “Amygdala and Neocortex: Common Origins and Shared Mechanisms” Nature Neuroscience 10 (9): 1081-1082
Editorial:
Tole S.
and Vale, R. (2010). Young leaders for
Biology in India. Science 329: 1441.
(Editorial)
Book Chapter:
Tole S.
and Hebert J. Telencephalon Patterning. “Cellular
Migration and Formation of Neuronal Connections:
Comprehensive Developmental Neuroscience” (2013) John
Rubenstein and PaskoRakic (Eds). Academic Press.
ISBN: 978-0-12-397265-1
Meeting Report:
Tole S.
and Shashidhara LS (2018)
Gender-sensitization in Indian science: attitudes and
action items” Tole and Shashidhara, 2018, in press,
Current Science
Personal story:
Nature Cell Biology’s “Turning
Points” series: Mentorship comes from many sources.
Tole, Nature Cell Biology
20:1010 (2018)
Blogs:
https://indiabioscience.org/authors/ShubhaTole
Taking the “ME” out of Mentorship
How to choose which institution or which lab to join?
One possible plug for the leaky pipeline
Are we doing enough?
How are we viewing collaborations?
Advice for students starting out in research
Advice for students starting out in
research
Contact
- Room B-304
- Tel: +91 22 2278 2878
- shubhatole @ gmail.com
- Webpage