Tata Institute of Fundamental Research


Vidita Vaidya

Professor (Chairperson)

Neurobiology of emotion


Life experiences have a profound impact on the brain. Our lab is interested in (1) understanding the neurocircuitry of emotion, (2) its modulation by experience and (3) the alterations in emotional neurocircuitry that underlie complex psychiatric disorders like depression. Using animal models of depression, some of which are based on perturbations of early life experience, we study the molecular, epigenetic and cellular changes that contribute to persistent alterations in behavior. We also study the molecular and cellular adaptations that arise from sustained antidepressant treatment. One such adaptation is the regulation of adult neural stem cells and we are interested in the pathways that regulate adult neurogenesis and their contribution to depression-related behavior. Our lab uses pharmacological and genetic approaches, and tools such as microarrays, in situ hybridization, immunohistochemistry and behavioral tests to understand the neurocircuitry of emotion.


Pati S, Saba K, Salvi SS, Tiwari P, Chaudhari PR, Verma V, Mukhopadhyay S, Kapri D, Suryavanshi S, Clement JP, Patel AB, Vaidya VA (2020) Chronic postnatal chemogenetic activation of forebrain excitatory neurons evokes persistent changes in mood behavior. Elife 2020 Sep 21;9:e56171. doi: 10.7554/eLife.56171. Link.

Fanibunda SE, Deb S, Maniyadath B, Tiwari P, Ghai U, Gupta S, Figueiredo D, Weisstaub N, Gingrich JA, Vaidya ADB, Kolthur-Seetharam U, Vaidya VA (2019) Serotonin regulates mitochondrial biogenesis and function in rodent cortical neurons via the 5-HT2A receptor and SIRT1–PGC-1α axis. PNAS, Link.

Sood A, Chaudhari K, Vaidya VA. (2018) Acute stress evokes sexually dimorphic, stressor-specific patterns of neural activation across multiple limbic brain regions in adult rats. Stress, DOI: 10.1080/10253890.2017.1422488.

Jaggar M, Weisstaub N, Gingrich JA, Vaidya VA. (2017) 5-HT2A receptor deficiency alters the metabolic and transcriptional, but not the behavioral, consequences of chronic unpredictable stress. Neurobiol. of Stress. 7:89-102.

Pusalkar M, Ghosh S, Jaggar M, Husain BF, Galande S, Vaidya VA. (2016) Acute and chronic electroconvulsive seizures (ECS) differentially regulate the expression of epigenetic machinery in the adult rat hippocampus. Int J Neuropsychopharmacol.

Sarkar A, Chachra P, Kennedy P, Pena CJ, Desouza LA, Nestler EJ, Vaidya VA. (2014) Hippocampal HDAC4 Contributes to Postnatal Fluoxetine-Evoked Depression-Like behavior. Neuropsychopharm.39(9):2221-32.

Sarkar A, Chachra P, Vaidya VA. (2014) Postnatal Fluoxetine-Evoked Anxiety Is Prevented by Concomitant 5HT2A/C receptor blockade and mimicked by postnatal 5HT2A/C receptor stimulation. Biol Psychiatry 76(11):858-68.

Suri D, Veenit V, Sarkar A, Thiagarajan D, Kumar A, Nestler EJ, Galande S, Vaidya VA. (2013) Early stress evokes age-dependent biphasic changes in hippocampal neurogenesis, Bdnf expression and cognition. Biol Psychiatry 73(7):658-66.


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  • vvaidya @ tifr.res.in
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