School of Natural Sciences
-
Deciphering the Catalytic Activity of an Orphan P450 enzyme
A systematically screened several fatty acids (saturated and monounsaturated) for their potential as substrates for CYP175A1 shows that the wild type enzyme could catalyze the reaction of mono-unsaturated fatty acids but not of saturated fatty acids...
-
Spin Dynamics: Electron Spin Polarization and Relaxation
Our research on Spin Dynamics attempts to understand mechanistic details that govern the generation electron spin systems in non-Boltzmann distribution and their evolution to Boltzmann distribution governed by the perturbing electron spin-lattice relaxation processes....
-
Single-Molecule Protein Mechanics
Single-molecule techniques are novel approaches to understand the structure-stability-function relationship of proteins, especially force spectroscopy methods in studying mechanically relevant proteins. These techniques are also useful to drive chemical reactions and bond-breakage at single-molecule/bond level to understand the reaction mechanism and get the elusive ‘transition state’ properties....
-
Rational Design of an Artificial Peroxidase
We have rationally modified the active site of this thermostable P450 to introduce a residue at the distal heme pocket that could act as an acid-base catalyst and thus enhance the peroxidase activity in the mutant enzyme. This could potentially lead to the creation of a thermally stable artificial peroxidase...
-
Proteins and the Computational Microscope
Theoretical modeling along with high performance computational simulations of biomolecules are probing how thermal motions of atoms drive diverse molecular scale processes such as charge transfer, enzymatic catalysis, biomolecular aggregation…..
About the Department
Scientists at the DCS explore the link between living systems and the physical laws that govern nature. They study molecules ranging in size as small as water and as large as a virus. The laws that govern interaction in molecules are best studied in well-defined and isolated small molecules. This information becomes applicable to design novel materials with exotic properties, of value to chemical and solar energy industries and to medical applications. To understand working of biological systems, studies are made on structure, dynamics and function of biological molecules. TIFR is a leader in state-of-the-art experimental techniques such as high field NMR, ultrafast lasers and single molecule methodologies.
News & events
-
Mr. Rohit won the 1st prize in Poster competition at 'Interdisciplinary conference in Materials Chemistry' held at BARC.
Mr. Rohit from Prof. Deepa Khushalani's group won 1st Prize for poster presentation at the "9th Interdisciplinary Symposium on Materials Chemistry" held at BARC Mumbai during December 7-10, 2022
-
11TH "FUTURE OF CHEMISTRY SYMPOSIUM" on November 14, 2022 (2.30 - 7.30 pm on zoom platform)
For detailed schedule please click here
-
Young Career Award in Nano Science & Technology for the year 2020 to Prof. Polshettiwar
Prof. Polshettiwar has been awarded Young Career Award in Nano Science & Technology for the year 2020 by Nano Mission, Department of Science & Technology, Government of India. He received the award during International Conference on Nano S&T (ICONSAT-2020) during 5-7 March, 2019 at Kolkata.
-
Congratulations to Khushalani and her group members for recognition of their research efforts!
- Best Poster Prize to Dr. Ashish Nadar (PDF in Khushalani Group) at Nano 2020 held in Bangalore in March 2020
- Invited Review article exclusively detailing work from Khushalani lab was showcased in ACS Langmuir along with the Front Cover for the print issue: Langmuir 2019, 35, 9101-9114
Best Poster Prize to Ashish Nadar at Nano 2020 held in Bangalore
Calendar
-
Seminar by Dr. Rikhia Ghosh, Icahn School of Medicine Mount Sinai, USA, on January 17, 2023 at 11.00 1m in AG-80
Title : Emergent Behavior of Living Matter: Different Pathways of Liquid Condensate Engulfment and Endocytosis by Membrane
-
Seminar by Dr. Rikhia Ghosh, Icahn School of Medicine Mount Sinai, USA, on January 16, 2023 at 4.00 pm in AG-69
Title : Structural and Dynamical Organization of Biomolecules: What are the Molecular Rules?
-
Seminar by Dr. Apoorva Badaya, Dept. of Chemical Sciences, TIFR Mumbai, on January 9, 2023 at 4.00 pm in AG-69
Title : Generating the charge transfer spectral profile of entire proteins
-
Seminar by Ms. Rishika Aggrawal, BITS Pilani, Hyderabad on January 4, 2023 at 5.00 pm via Zoom Platform
Title : Steady-State and Time-Resolved Fluorescence Spectroscopic Studies to Probe Physicochemical Processes in Various Self-Assembled Molecular Systems
-
Seminar by Dr. Sudarshan Vijay, Department of Materials Science, University of California Berkeley, USA on January 3, 2023 at 2.00 pm in AG-69
Title : Effect of the electrode-electrolyte interface on the activity of a heterogeneous catalyst: developing and applying new methods