Title :

Metabolic Paradigm of Sleep

Abstract :

Reduced sleep duration is a hallmark of modern-day society and is increasingly associated with medical conditions, such as diabetes, obesity, metabolic syndrome, and cardiovascular disease. Therefore, altered metabolism is a key to understand the processes related to sleep debt and clinical conditions associated to sleep. A metabolomic investigation by our lab has shown significant metabolic alteration in sleep deprived mice compared to baseline metabolic status. Major circulatory lipid component was found to be altered. In addition, we also showed presence of cross-species metabolic markers of sleep debt across rodents and humans. In addition, we also made progress investigating metabolic correlates of brain function during sleep. These results will be discussed in light of the clinical phenotypes of reduced sleep and sleep disorders.