Title :

Studies on Transition Metal Complexes of Flexible Polydentate Schiff Base Ligands 

Abstract :

The primary objective of this research work was to explore the structure-activity relationship between several kinds of biological, chemical as well as material properties and various complex structures tuned by flexible Schiff base ligands. In this regards several Ni(II) and Cu(II) Schiff base complexes have been synthesized by exploiting the flexibility of the piperazinyl moiety. The specific effectiveness towards DNA/Protein binding and catecholase like properties was observed due to flexibility and nuclearity in case of nickel and copper complexes respectively. Furthermore an interesting counter anion directed flexibility was observed in metal complexes after little modification in Schiff base ligands. Apart from protease, nuclease and catecholase like activities, these complexes have shown effective cytotoxicity towards HeLa cells.

Pseudo-halide promoted and nuclearity driven enhanced corrosion inhibition activity of Zn(II) and Cd(II) Schiff base complexes was also observed to investigate the material applications of Schiff base complexes.

Thus, it could be the stepping stone for further tuning of ligand using flexibility and to develop high nuclearity coordination compounds for more effectiveness in terms of biological and material applications.