Basuthkar J. Rao
Senior Professor
Department of Chemical Sciences
Room B-202
Department of Chemical Sciences
Tata Institute of Fundamental Research, Homi Bhabha Road, Colaba, Mumbai 400005
+91 22 2278 2606
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  • Current Research
  • Selected Publications

We are curious about many biological issues that we work on: mapping and understanding the promiscuity scores of protein active sites using computational approaches; dissecting the biochemical mechanism of regulation of homologous recombination by tumour suppressors such as P53 and BRCA2 proteins, Chromosome territory movements associated with DNA damage response events in mammalian cells; Circadian control of UV-sensitivity in Chlamydomonas reinhardii; Cell biology and metabolism in Chlamydomonas reinhardtii during adaptive stress responses etc. We seek to address these issues from the mechanistic point of view. In addition, we are also involved in collaborative projects with chemists and physicists at TIFR to seek answers for how “soft electrons” (~10eV) intersect and change biomolecules, Rules followed by RNA aptamers while specifically recognizing small ligands such as GTP, developing methods to study in cell metabolism by solution NMR strategies etc.

So the efforts we are involved in are rather diverse, but exciting as they uncover very new information. Our efforts traverse through biological processes that encompass several orders of time scales.

  • Chakraborty S, Rao BJ (2012) A measure of the promiscuity of proteins and characteristics of residues in the vicinity of the catalytic site that regulate promiscuity. PLoS One 7: e32011
  • Kumar SVK, Pota T, Peri D, Dongre AD, Rao BJ (2012) Low energy electron induced damage to plasmid DNA pQE30. Journal of Physical Chemistry 137: 045101
  • D’Souza JS, Dharmadhikari JA, Dharmadhikari AK, Rao BJ, Mathur D (2011) Effect of intense, ultrashort laser pulses on DNA plasmids in their native state: strand breakages induced by in situ electrons and radicals. Physical Review Letters 106: 118101
  • Chakraborty S, Minda R, Salaye L, Bhattacharjee SK, Rao BJ (2011) Active site detection by spatial conformity and electrostatic analysis - unravelling a proteolytic function in shrimp alkaline phosphatase. PLoS One 6: e28470
  • Noothi SK, Rao BJ (2009) MutS and UvrD proteins stimulate exonuclease action: insights on exonuclease mediated strand repairs. Biochemistry 48: 7787
  • Krishnan NM, Rao BJ (2009) A comparative approach to elucidate chloroplast genome replication. BMC Genomics 10: 237