October 28, 2013 at 4.00 pm in AG-69
Title :Chemical approaches and nanoparticle technologies in biology: from live cell imaging to programming biology
Tailoring the properties of nanomaterials by employing chemical tools is crucial for their potential applications in various biomedical research. In this talk I will detail my research on integrating photochemical and synthetic supramolecular chemical tools with nanomaterials for developing state-of-the-art molecular imaging techniques and creatingnovel sensing and therapeutic approaches.Additionally, I will describe an in vivo translation of light regulated system for programming biology, where we havecreated an optochemogenetic switch to regulate temporal- and cell-specific gene expression in mice.
January 13, 2014 at 4.00 pm in AG-69
Title: Fibrils, membranes, crystals, sediments: solid-state NMR of large proteins
Solid-state NMR is an increasingly powerful tool to characterize challenging proteins. Notably, it can analyze an astonishing variety of states, as proteins inserted in membranes, crystals and simple sediments. Combined with other biophysical approaches, solid-state NMR thus gives unique insight into protein structure, and ultimately function. We will illustrate this with some recent examples from our laboratories, including the DnaB helicase from Helicobacter pilori, the BmrA ABC transporter, as well as the yeast prion fibrils Ure2p and Sup35p, for which we will show results related to sample preparation, sequential assignments and structural aspects.
October 29, 2013 at 11.30 am in AG-80
Title : Molecularly resolved single cell:diagnostics andin vivo imaging
The ability to analyze as well as spatially resolve protein signaturesat single cell resolution is becoming increasingly important in biological research, forensic science as well as in clinical diagnostics.This talk will focus on detailing approaches for single cell isolation to single cell protein signature analysis.A method based on DNA barcoding of cellular proteins will be described for rapid, quantitative and multiplexed detection of scant proteins and antigens in single live cell. I will also describe novel imaging techniques for molecularly resolving and mapping protein signatures in vivo.
November 11, 2013 at 4.00 pm in AG-69
Title : To be announced
October 22, 2013 at 11.30 am in AG-80
Title : Coupling of Computational and Experimental Methods to Solve Real World Problems: From Reactive Intermediates to Green Chemistry