Booking


Please contact nmr@tifr.res.in  for booking/appointment.

Information that can be obtained from NMR Spectra

Information about the structure, conformation and dynamics of small and large molecules can be obtained in the solution and solid state. However, in view of the fact that adequate facilities for low field NMR exist in the country, the high resolution Facility will undertake only such problems, which cannot be solved at other Facilities. For an efficient use of the Facility it is advisable that the User bring a low field NMR spectrum on the same sample and concentration.

Sample Requirement

The high field (better sensitivity) along with signal averaging, should in principle give a signal for samples of low concentration if scanned for long duration. With the inherent limitations of the NMR spectrometer coupled with the high cost of spectrometer time particularly for sophisticated spectra, it is advantageous to work with maximum possible concentration of samples. For low molecular weight (MW < 250) compounds a minimum of 1-3 mg and for high molecular weight 2-5 mg of samples should be provided for proton spectra. For proton decoupled Carbon-13 spectra, 50-100 mg of sample will be required. For 13P spectra 5-20 mg of sample will be required. For solid state NMR sample requirement is ~ 100 mgs.

Solvent Requirement

For ensuring magnetic field stability and adjusting field homogeneity, a deuterium lock channel is provided. Therefore, samples are to be dissolved in a deuterated solvent. Deuterated solvents like D2O, CDCl3, are provided by the Facility free of cost. However Users have to pay for expensive solvents such as CD3COCD3, DMSOd6, C6D6, etc.. The User should check the solubility of the sample in any of these solvents (of course, in undeuterated solvent) and suggest best solvent. For certain specialized experiments high isotopic enrichment or depletion in the solvent may be desirable. The Facility cannot provide such solvents and the Users should bring such solvents whenever necessary.

Charges

For users from academic institutions, the rates for the solution state 500 MHz  spectrometers’ usage are Rs. 800 per hour or per sample, whichever is higher. For 600MHz, 700 MHz and 800 MHz spectrometer the rate shall be Rs. 1000. In addition, the users shall pay for the cost of the solvents except CDCl3 and D2O. For solid state experiments charges for 500 MHz and 700 MHz shall be Rs. 1000/- for academic institute, whereas for the industries charges will be Rs 7000 on both these spectrometer.

It is important to note that a two and three dimensional NMR spectrum could be quite expensive. In case of financial hardships, a written request for waiver of charges should be made along with the requisition slip giving full justification for the waiver. Once the bill for the machine time used is prepared, it will not be possible to modify or cancel it.

 

Charges in Indian Rupees (INR) w.e.f. June 1, 2012

  500MHz 600MHz 700MHz 800MHz
  Academic Industry Academic Industry Academic Industry Academic Industry
Solution State 800 5000 1000 5000 1000 7000 1000 7000
Solid State 1000 7000     1000 7000    

Cheque / Draft should be drawn in favor of : TIFR, Mumbai

Research Proposals

The major Users requiring more than 50 hours of machine time per annum are requested to submit a brief research proposal regarding the nature of their studies on the 500 MHz, 600 MHz, 700 MHz and 800 MHz NMR spectrometers which will be discussed periodically by the Program Advisory Committee (PAC) of the Facility. The Users are requested also to send a list of publications which have come out as a result of facilities provided by the Facility. On the basis of the research proposal, the PAC may set up priorities for certain programs which in their opinion fall in the emerging areas. Such a proposal is not necessary for Users who want to run high field NMR for a few samples where low field NMR has not been very informative. A Performa for the proposal for the use of the Facility is given on the next page.

Training

Most of the Users need extensive usage of the Facility. For an efficient use of the Facility, it is desirable that some of the younger scientists from each User laboratory are trained. Except for routine spectra, the Users' presence is essential. Arrangements for lodging can be made in the TIFR Guest House for outstation Users if a request is received well in advance.

 

Acknowledgements

Facility users are required to acknowledge the usage of the Facility in all publications.